8UW9

Structure of AKT1(E17K) with compound 4

Summary for 8UW9

• Entry DOI: 10.2210/pdb8uw9/pdb
• Related: 8UVY 8UW2 8UW7
• Descriptor: RAC-alpha serine/threonine-protein kinase, NB41, N-({4-[(2P)-2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}methyl)-2-(2-fluoro-4-formyl-3-hydroxyphenyl)acetamide, ... (8 entities in total)
• Functional Keywords: inhibitor, kinase, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 66309.97

Authors

Craven, G.B.,Taunton, J. (deposition date: 2023-11-06, release date: 2024-09-04, Last modification date: 2024-10-23)

• Primary citation: Craven, G.B.,Taunton, J.; Mutant-selective AKT1 inhibitors via lysine targeting and neo-zinc chelation; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)