8UW9
Structure of AKT1(E17K) with compound 4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | RAC-alpha serine/threonine-protein kinase | polymer | 438 | 51153.5 | 1 | UniProt (P31749) Pfam (PF00169) Pfam (PF00069) Pfam (PF00433) In PDB | Homo sapiens (human) | |
| 2 | B | NB41 | polymer | 126 | 13912.6 | 1 | Lama glama | ||
| 3 | A | N-({4-[(2P)-2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}methyl)-2-(2-fluoro-4-formyl-3-hydroxyphenyl)acetamide | non-polymer | 572.6 | 1 | Chemie (XQ2) | |||
| 4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | A | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 6 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 7 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | water | water | 18.0 | 155 | Chemie (HOH) |
Sequence modifications
A: 2 - 446 (UniProt: P31749)
| PDB | External Database | Details |
|---|---|---|
| Lys 17 | Glu 17 | conflict |
| - | Phe 120 | deletion |
| Ala 120 | Arg 121 | conflict |
| Ala 122 | Gly 123 | conflict |
| Glu 123 | Ser 124 | conflict |
| His 124 | Pro 125 | conflict |
| Thr 125 | Ser 126 | conflict |
| - | Asn 128 | deletion |
| - | Ser 129 | deletion |
| - | Gly 130 | deletion |
| - | Ala 131 | deletion |
| - | Glu 132 | deletion |
| - | Glu 133 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65066.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1243.9 | |
| All* | Total formula weight | 66310.0 |
