8UW8

Site-one protease and SPRING

Summary for 8UW8

• Entry DOI: 10.2210/pdb8uw8/pdb
• EMDB information: 42639
• Descriptor: Membrane-bound transcription factor site-1 protease, SREBP regulating gene protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: serine protease cholesterol metabolism zymogen activation protein complex glycoprotein secretory pathway, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 139096.32

Authors

Kober, D.L. (deposition date: 2023-11-06, release date: 2024-07-10)

• Primary citation: Hendrix, S.,Dartigue, V.,Hall, H.,Bawaria, S.,Kingma, J.,Bajaj, B.,Zelcer, N.,Kober, D.L.; SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain; Nat Commun, 2024; DOI: 10.1038/s41467-024-50068-8

Experimental method

ELECTRON MICROSCOPY (2.3 Å)