8UW1
Cryo-EM structure of DNMT3A1 UDR in complex with H2AK119Ub-nucleosome
Summary for 8UW1
Entry DOI | 10.2210/pdb8uw1/pdb |
EMDB information | 42636 |
Descriptor | Histone H3.2, Histone H4, Histone H2A, ... (7 entities in total) |
Functional Keywords | dnmt3a1, chromatin, h2a lysine 119 monoubiquitination, dna methyltransferase, gene regulation |
Biological source | Xenopus laevis (African clawed frog) More |
Total number of polymer chains | 11 |
Total formula weight | 208966.33 |
Authors | Gretarsson, K.,Abini-Agbomson, S.,Armache, K.-J.,Lu, C. (deposition date: 2023-11-05, release date: 2024-09-11) |
Primary citation | Gretarsson, K.H.,Abini-Agbomson, S.,Gloor, S.L.,Weinberg, D.N.,McCuiston, J.L.,Kumary, V.U.S.,Hickman, A.R.,Sahu, V.,Lee, R.,Xu, X.,Lipieta, N.,Flashner, S.,Adeleke, O.A.,Popova, I.K.,Taylor, H.F.,Noll, K.,Windham, C.L.,Maryanski, D.N.,Venters, B.J.,Nakagawa, H.,Keogh, M.C.,Armache, K.J.,Lu, C. Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch. Sci Adv, 10:eadp0975-eadp0975, 2024 Cited by PubMed: 39196936DOI: 10.1126/sciadv.adp0975 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.88 Å) |
Structure validation
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