8UVM

SARS-CoV-2 papain-like protease (PLpro) complex with covalent inhibitor Jun11313

8UVM の概要

• エントリーDOI: 10.2210/pdb8uvm/pdb
• 分子名称: Papain-like protease nsp3, ethyl 4-oxo-4-(2-{3-[2-({(1S)-1-[(3P)-3-(thiophen-3-yl)phenyl]ethyl}carbamoyl)phenyl]propanoyl}hydrazinyl)butanoate, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: sars cov-2 papain like protease complex, covalent inhibitor, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, 2019-nCoV, COVID-19 virus)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 146684.71

構造登録者

Ansari, A.,Tan, B.,Chopra, A.,Ruiz, F.X.,Arnold, E.,Wang, J. (登録日: 2023-11-03, 公開日: 2024-04-03, 最終更新日: 2024-05-01)

• 主引用文献: Tan, B.,Zhang, X.,Ansari, A.,Jadhav, P.,Tan, H.,Li, K.,Chopra, A.,Ford, A.,Chi, X.,Ruiz, F.X.,Arnold, E.,Deng, X.,Wang, J.; Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model.; Science, 383:1434-1440, 2024; PubMed: 38547259; DOI: 10.1126/science.adm9724

実験手法

X-RAY DIFFRACTION (2.85 Å)