8UQV

Trehalose Synthase (TreS) of Mycobacterium tuberculosis in complex with 6-TreAz compound

Summary for 8UQV

Entry DOI	10.2210/pdb8uqv/pdb
EMDB information	42478
Descriptor	Trehalose synthase/amylase TreS, alpha-D-glucopyranose, 6-azido-6-deoxy-alpha-D-glucopyranose, ... (5 entities in total)
Functional Keywords	tres, trehalose synthase, mycobacterium tuberculosis, 6-treaz, cytosolic protein
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	4
Total formula weight	264871.96
Authors	Pathirage, R.,Ronning, D.R. (deposition date: 2023-10-24, release date: 2024-03-27, Last modification date: 2024-04-24)
Primary citation	Kalera, K.,Liu, R.,Lim, J.,Pathirage, R.,Swanson, D.H.,Johnson, U.G.,Stothard, A.I.,Lee, J.J.,Poston, A.W.,Woodruff, P.J.,Ronning, D.R.,Eoh, H.,Swarts, B.M. Targeting Mycobacterium tuberculosis Persistence through Inhibition of the Trehalose Catalytic Shift. Acs Infect Dis., 10:1391-1404, 2024 Cited by PubMed: 38485491 DOI: 10.1021/acsinfecdis.4c00138 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation