8UFU
Structure of human endothelial nitric oxide synthase heme domain in complex with 7-(9-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-4-methylquinolin-2-amine
Summary for 8UFU
Entry DOI | 10.2210/pdb8ufu/pdb |
Descriptor | Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, (7M)-7-[(9S)-9-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]-4-methylquinolin-2-amine, ... (10 entities in total) |
Functional Keywords | nitric oxide synthase inhibitor, heme enzyme, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 205267.57 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2023-10-04, release date: 2024-03-13, Last modification date: 2024-04-03) |
Primary citation | Li, H.,Hardy, C.D.,Reidl, C.T.,Jing, Q.,Xue, F.,Cinelli, M.,Silverman, R.B.,Poulos, T.L. Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase. Biochemistry, 63:788-796, 2024 Cited by PubMed: 38417024DOI: 10.1021/acs.biochem.3c00601 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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