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8UFU

Structure of human endothelial nitric oxide synthase heme domain in complex with 7-(9-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-4-methylquinolin-2-amine

Summary for 8UFU
Entry DOI10.2210/pdb8ufu/pdb
DescriptorNitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, (7M)-7-[(9S)-9-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]-4-methylquinolin-2-amine, ... (10 entities in total)
Functional Keywordsnitric oxide synthase inhibitor, heme enzyme, oxidoreductase
Biological sourceHomo sapiens (human)
Total number of polymer chains4
Total formula weight205267.57
Authors
Li, H.,Poulos, T.L. (deposition date: 2023-10-04, release date: 2024-03-13, Last modification date: 2024-04-03)
Primary citationLi, H.,Hardy, C.D.,Reidl, C.T.,Jing, Q.,Xue, F.,Cinelli, M.,Silverman, R.B.,Poulos, T.L.
Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase.
Biochemistry, 63:788-796, 2024
Cited by
PubMed: 38417024
DOI: 10.1021/acs.biochem.3c00601
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.05 Å)
Structure validation

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PDB entries from 2024-04-24

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