8UFU
Structure of human endothelial nitric oxide synthase heme domain in complex with 7-(9-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-4-methylquinolin-2-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Nitric oxide synthase, endothelial | polymer | 440 | 49345.8 | 4 | UniProt (P29474) Pfam (PF02898) | Homo sapiens (human) | Constitutive NOS,cNOS,EC-NOS,Endothelial NOS,eNOS,NOS type III,NOSIII |
| 2 | E, IA, O, W (A, D, B, C) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, FA, G, JA, P... (A, C, D, B) | (7M)-7-[(9S)-9-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]-4-methylquinolin-2-amine | non-polymer | 317.4 | 8 | Chemie (WRI) | |||
| 4 | AA, H, I, KA, LA... (C, A, D, B) | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 8 | Chemie (BTB) | |||
| 5 | BA, J, MA (C, A, D) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | CA, K, NA, T (C, A, D, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 7 | DA, EA, GA, L, M... (C, A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 8 | HA, N (C, A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 9 | OA, U (D, B) | GADOLINIUM ATOM | non-polymer | 157.3 | 2 | Chemie (GD) | |||
| 10 | PA, QA, RA, SA (A, B, C, D) | water | water | 18.0 | 362 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 41 - 480 (UniProt: P29474)
| PDB | External Database | Details |
|---|---|---|
| Glu 298 | Asp 298 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 197383.1 | |
| Non-Polymers* | Number of molecules | 37 |
| Total formula weight | 7884.5 | |
| All* | Total formula weight | 205267.6 |
