8UFQ

Structure of human neuronal nitric oxide synthase R354A/G357D/E597Q mutant heme domain obtained after soaking crystal with 4-methyl-7-(4-methyl-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-7-yl)quinolin-2-amine dihydrochloride

Summary for 8UFQ

• Entry DOI: 10.2210/pdb8ufq/pdb
• Descriptor: Nitric oxide synthase 1, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ... (6 entities in total)
• Functional Keywords: nitric oxide synthase inhibitor, heme enzyme, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 200465.88

Authors

Li, H.,Poulos, T.L. (deposition date: 2023-10-04, release date: 2024-03-13, Last modification date: 2024-04-03)

• Primary citation: Li, H.,Hardy, C.D.,Reidl, C.T.,Jing, Q.,Xue, F.,Cinelli, M.,Silverman, R.B.,Poulos, T.L.; Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase.; Biochemistry, 63:788-796, 2024; PubMed: 38417024; DOI: 10.1021/acs.biochem.3c00601

Experimental method

X-RAY DIFFRACTION (1.98 Å)