8UFQ
Structure of human neuronal nitric oxide synthase R354A/G357D/E597Q mutant heme domain obtained after soaking crystal with 4-methyl-7-(4-methyl-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-7-yl)quinolin-2-amine dihydrochloride
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Nitric oxide synthase 1 | polymer | 423 | 48995.8 | 4 | UniProt (P29475) Pfam (PF02898) | Homo sapiens (human) | |
| 2 | E, L, O, V (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, G, H, M, N... (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 10 | Chemie (GOL) | |||
| 4 | I, T (A, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | J, K, P, U (A, B, C) | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 4 | Chemie (H4B) | |||
| 6 | AA, BA, Y, Z (C, D, A, B) | water | water | 18.0 | 1193 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 302 - 722 (UniProt: P29475)
| PDB | External Database | Details |
|---|---|---|
| Ala 354 | Arg 354 | engineered mutation |
| Asp 357 | Gly 357 | engineered mutation |
| Gln 597 | Glu 597 | engineered mutation |
| Leu 723 | - | expression tag |
| Val 724 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 195983.2 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 4482.7 | |
| All* | Total formula weight | 200465.9 |
