8UCD

Cryo-EM structure of human STEAP1 in complex with AMG 509 Fab

Summary for 8UCD

• Entry DOI: 10.2210/pdb8ucd/pdb
• EMDB information: 42124
• Descriptor: Metalloreductase STEAP1, AMG 509 anti-STEAP1 Fab, heavy chain, AMG 509 anti-STEAP1 Fab, light chain, ... (7 entities in total)
• Functional Keywords: membrane protein, antibody, cancer, membrane protein-immune system complex, membrane protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 173750.62

Authors

Li, F.,Bailis, J.M.,Zhang, H. (deposition date: 2023-09-26, release date: 2023-11-22, Last modification date: 2024-01-24)

• Primary citation: Nolan-Stevaux, O.,Li, C.,Liang, L.,Zhan, J.,Estrada, J.,Osgood, T.,Li, F.,Zhang, H.,Case, R.,Murawsky, C.M.,Estes, B.,Moore, G.L.,Bernett, M.J.,Muchhal, U.,Desjarlais, J.R.,Staley, B.K.,Stevens, J.,Cooke, K.S.,Aeffner, F.,Thomas, O.,Stieglmaier, J.,Lee, J.L.,Coxon, A.,Bailis, J.M.; AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer.; Cancer Discov, 14:90-103, 2024; PubMed: 37861452; DOI: 10.1158/2159-8290.CD-23-0984

Experimental method

ELECTRON MICROSCOPY (3 Å)