8UCD
Cryo-EM structure of human STEAP1 in complex with AMG 509 Fab
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005768 | cellular_component | endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005911 | cellular_component | cell-cell junction |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052851 | molecular_function | ferric-chelate reductase (NADPH) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005768 | cellular_component | endosome |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005911 | cellular_component | cell-cell junction |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0020037 | molecular_function | heme binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052851 | molecular_function | ferric-chelate reductase (NADPH) activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005768 | cellular_component | endosome |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0005911 | cellular_component | cell-cell junction |
| C | 0010008 | cellular_component | endosome membrane |
| C | 0016020 | cellular_component | membrane |
| C | 0020037 | molecular_function | heme binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0052851 | molecular_function | ferric-chelate reductase (NADPH) activity |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR312-HIS318 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 320 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q687X5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"32409586","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6Y9B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
