8UCD
Cryo-EM structure of human STEAP1 in complex with AMG 509 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Metalloreductase STEAP1 | polymer | 352 | 41215.3 | 3 | UniProt (Q9UHE8) Pfam (PF01794) | Homo sapiens (human) | |
| 2 | D (H) | AMG 509 anti-STEAP1 Fab, heavy chain | polymer | 188 | 20227.5 | 1 | Homo sapiens | ||
| 3 | E (L) | AMG 509 anti-STEAP1 Fab, light chain | polymer | 213 | 23391.0 | 1 | Homo sapiens | ||
| 4 | F, H, J (A, B) | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine | non-polymer | 760.1 | 3 | Chemie (LBN) | |||
| 5 | G, K, M (A, B, C) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 3 | Chemie (FAD) | |||
| 6 | I, L, N (A, B, C) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 3 | Chemie (HEM) | |||
| 7 | O (C) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 339 (UniProt: Q9UHE8)
| PDB | External Database | Details |
|---|---|---|
| Gly 340 | - | expression tag |
| Gly 341 | - | expression tag |
| Gly 342 | - | expression tag |
| Gly 343 | - | expression tag |
| Ser 344 | - | expression tag |
| Asp 345 | - | expression tag |
| Tyr 346 | - | expression tag |
| Lys 347 | - | expression tag |
| Asp 348 | - | expression tag |
| Asp 349 | - | expression tag |
| Asp 350 | - | expression tag |
| Asp 351 | - | expression tag |
| Lys 352 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 167264.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 6486.3 | |
| All* | Total formula weight | 173750.6 |
