8UCC
IRAK4 in complex with compound 20
Summary for 8UCC
Entry DOI | 10.2210/pdb8ucc/pdb |
Related | 8UCB |
Descriptor | Interleukin-1 receptor-associated kinase 4, (4S)-2-[(1R,4s)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-N-[(8S)-6-methylpyrazolo[1,5-a]pyrimidin-3-yl]-7-[(propan-2-yl)oxy]imidazo[1,2-a]pyrimidine-6-carboxamide, ... (4 entities in total) |
Functional Keywords | kinase, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 69970.92 |
Authors | |
Primary citation | Evans, R.,Bolduc, P.N.,Pfaffenbach, M.,Gao, F.,May-Dracka, T.,Fang, T.,Hopkins, B.T.,Chodaparambil, J.V.,Henry, K.L.,Li, P.,Metrick, C.,Nelson, A.,Trapa, P.,Thomas, A.,Burkly, L.,Peterson, E.A. The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)- N -(6-methylpyrazolo[1,5- a ]pyrimidin-3-yl)imidazo[1,2- a ]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke. J.Med.Chem., 67:4676-4690, 2024 Cited by PubMed: 38467640DOI: 10.1021/acs.jmedchem.3c02226 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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