8U7H
Cryo-EM structure of LRRK2 bound to type I inhibitor GNE-7915
Summary for 8U7H
Entry DOI | 10.2210/pdb8u7h/pdb |
EMDB information | 41982 |
Descriptor | non-specific serine/threonine protein kinase, GUANOSINE-5'-DIPHOSPHATE, [4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoranyl-5-methoxy-phenyl]-morpholin-4-yl-methanone (3 entities in total) |
Functional Keywords | cryo-em, parkinson's disease, kinase, lrrk2, type i inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 137730.07 |
Authors | |
Primary citation | Zhu, H.,Hixson, P.,Ma, W.,Sun, J. Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM. Cell Discov, 10:10-10, 2024 Cited by PubMed: 38263358DOI: 10.1038/s41421-023-00639-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.8 Å) |
Structure validation
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