8U6G

Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 3-(2-(2-(3-acryloyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)ethoxy)-4-chlorophenoxy)-5-chlorobenzonitrile (JLJ744), a non-nucleoside inhibitor

Summary for 8U6G

Entry DOI	10.2210/pdb8u6g/pdb
Descriptor	Reverse transcriptase/ribonuclease H, p51 RT, 3-chloro-5-{4-chloro-2-[2-(2-oxo-3-propanoyl-2,3-dihydro-1H-benzimidazol-1-yl)ethoxy]phenoxy}benzonitrile, ... (5 entities in total)
Functional Keywords	reverse transcriptase, antiviral, drug design, hiv-1, viral protein
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	2
Total formula weight	114445.54
Authors	Prucha, G.,Carter, Z.,Jorgensen, W.L.,Anderson, K.S. (deposition date: 2023-09-13, release date: 2023-11-08)
Primary citation	Prucha, G.R.,Henry, S.,Hollander, K.,Carter, Z.J.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S. Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262:115894-115894, 2023 Cited by PubMed: 37883896 DOI: 10.1016/j.ejmech.2023.115894 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.77 Å)

Structure validation