8U5I

Crystal Structure of human IDO1 bound to Compound 23

Summary for 8U5I

• Entry DOI: 10.2210/pdb8u5i/pdb
• Descriptor: Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, (1R,2S)-8-(ethanesulfonyl)-2-[(4R,5S,9aM)-5H-imidazo[5,1-a]isoindol-5-yl]-8-azaspiro[4.5]decan-1-ol, ... (4 entities in total)
• Functional Keywords: ido, tdo, complex, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 90746.22

Authors

Steinbacher, S.,Lammens, A.,Harris, S.F. (deposition date: 2023-09-12, release date: 2024-11-27)

• Primary citation: Pastor, R.,Harris, S.F.; Exploiting Stereo-Complexity to Identify Spirocyclic Imidazoisoindoles as Potent and Orally Bioavailable Dual Inhibitors of Indoleamine-2,3-Dioxygenase and Tryptophan-2,3-Dioxygenase; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.17 Å)