8U0O

Synaptic complex of human DNA polymerase Lambda DL variant engaged on a DNA double-strand break containing an unpaired 3' primer terminus

Summary for 8U0O

• Entry DOI: 10.2210/pdb8u0o/pdb
• Descriptor: DNA polymerase lambda, DNA (5'-D(*AP*CP*GP*CP*GP*GP*CP*A)-3'), DNA (5'-D(P*GP*CP*CP*GP*CP*GP*TP*A)-3'), ... (8 entities in total)
• Functional Keywords: nonhomologous end-joining, base excision repair, dna polymerase, transferase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 43080.20

Authors

Kaminski, A.M.,Pedersen, L.C.,Bebenek, K.,Kunkel, T.A.,Chiruvella, K.K.,Ramsden, D.A. (deposition date: 2023-08-29, release date: 2024-03-13)

• Primary citation: Kaminski, A.M.,Chiruvella, K.K.,Ramsden, D.A.,Bebenek, K.,Kunkel, T.A.,Pedersen, L.C.; DNA polymerase lambda Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining.; DNA Repair (Amst), 136:103645-103645, 2024; PubMed: 38428373; DOI: 10.1016/j.dnarep.2024.103645

Experimental method

X-RAY DIFFRACTION (2.05 Å)