8TZX

Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue dWIZ-1

8TZX の概要

• エントリーDOI: 10.2210/pdb8tzx/pdb
• 分子名称: Protein cereblon, DNA damage-binding protein 1, Protein Wiz, ... (8 entities in total)
• 機能のキーワード: complex, glue, ligase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 280743.67

構造登録者

Clifton, M.C.,Ma, X.,Ornelas, E. (登録日: 2023-08-28, 公開日: 2024-07-10)

• 主引用文献: Ting, P.,Reyes, A.,Fodor, B.D.,Wu, F.,Belew, M.S.,Mao, X.,Wang, J.,Chitnis, S.,Niu, W.,Hachey, A.,Cobb, J.S.,Savage, N.A.,Burke, A.,Paulk, J.,Dovala, D.,Lin, J.,Clifton, M.C.,Ornelas, E.,Ma, X.,Ware, N.F.,Sanchez, C.C.,Trarszka, J.,Terranova, R.,Knehr, J.,Altorfer, M.,Barnes, S.W.,Beckwith, R.E.J.,Solomon, J.M.,Dales, N.A.,Patterson, A.W.,Wagner, J.,Bouwmeester, T.,Dranoff, G.,Stevenson, S.C.,Bradner, J.E.; Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue dWIZ-1; Science, 2024; DOI: 10.1126/science.adk6129

実験手法

X-RAY DIFFRACTION (3.15 Å)