8TRS

Structure of the EphA2 CRD bound to FabS1CE_C1, trigonal form

8TRS の概要

• エントリーDOI: 10.2210/pdb8trs/pdb
• 関連するPDBエントリー: 8TRS 8TRT 8TRV
• 分子名称: S1CE variant of Fab C1 heavy chain, S1CE variant of Fab C1 light chain, Ephrin type-A receptor 2, ... (8 entities in total)
• 機能のキーワード: cell signalling, antibody, agonist, high affinity, clustering, activation, signaling protein-immune system complex, signaling protein/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 63826.23

構造登録者

Singer, A.U.,Bruce, H.A.,Blazer, L.,Adams, J.J.,Sicheri, F.,Sidhu, S.S. (登録日: 2023-08-10, 公開日: 2023-11-22, 最終更新日: 2024-01-10)

• 主引用文献: Bruce, H.A.,Singer, A.U.,Filippova, E.V.,Blazer, L.L.,Adams, J.J.,Enderle, L.,Ben-David, M.,Radley, E.H.,Mao, D.Y.L.,Pau, V.,Orlicky, S.,Sicheri, F.,Kurinov, I.,Atwell, S.,Kossiakoff, A.A.,Sidhu, S.S.; Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.; Protein Sci., 33:e4824-e4824, 2024; PubMed: 37945533; DOI: 10.1002/pro.4824

実験手法

X-RAY DIFFRACTION (1.9 Å)