8TO4

EGFR(T790M/V948R) in complex with the allosteric inhibitor FRF-06-057

Summary for 8TO4

• Entry DOI: 10.2210/pdb8to4/pdb
• Descriptor: Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
• Functional Keywords: kinase, inhibitor, cancer, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 152766.25

Authors

Chitnis, S.P.,Deng, M.Q.,Pham, C.P.,Heppner, D.E. (deposition date: 2023-08-02, release date: 2024-08-28)

• Primary citation: Chitnis, S.P.,Pham, C.D.,Deng, M.Q.,Heppner, D.E.; EGFR(T790M/V948R) in complex with the allosteric inhibitor FRF-06-057; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.99 Å)