8THR

Structure of the human vesicular monoamine transporter 2 (VMAT2) bound to tetrabenazine in an occluded conformation

Summary for 8THR

Entry DOI	10.2210/pdb8thr/pdb
EMDB information	41269
Descriptor	fluorescent protein mVenus,Synaptic vesicular amine transporter,GFP nano body,Synaptic vesicular amine transporter,Synaptic vesicular amine transporter, (3S,5R,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one (2 entities in total)
Functional Keywords	monoamine, neurotransmitter, synaptic vesicles, major facilitator superfamily, slc18, transport protein
Biological source	Aequorea victoria More
Total number of polymer chains	1
Total formula weight	94168.35
Authors	Dalton, M.P.,Coleman, J.A. (deposition date: 2023-07-17, release date: 2023-10-25, Last modification date: 2024-05-08)
Primary citation	Dalton, M.P.,Cheng, M.H.,Bahar, I.,Coleman, J.A. Structural mechanisms for VMAT2 inhibition by tetrabenazine. Elife, 12:-, 2024 Cited by PubMed: 38517752 DOI: 10.7554/eLife.91973 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.12 Å)

Structure validation