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8THR

Structure of the human vesicular monoamine transporter 2 (VMAT2) bound to tetrabenazine in an occluded conformation

Functional Information from GO Data
ChainGOidnamespacecontents
A0001975biological_processresponse to amphetamine
A0002552biological_processserotonin secretion by mast cell
A0002553biological_processhistamine secretion by mast cell
A0005335molecular_functionserotonin:sodium:chloride symporter activity
A0005515molecular_functionprotein binding
A0005813cellular_componentcentrosome
A0005886cellular_componentplasma membrane
A0006091biological_processgeneration of precursor metabolites and energy
A0006836biological_processneurotransmitter transport
A0007268biological_processchemical synaptic transmission
A0007626biological_processlocomotory behavior
A0008021cellular_componentsynaptic vesicle
A0008218biological_processbioluminescence
A0008504molecular_functionmonoamine transmembrane transporter activity
A0009636biological_processresponse to toxic substance
A0009791biological_processpost-embryonic development
A0015311molecular_functionmonoamine:proton antiporter activity
A0015842biological_processaminergic neurotransmitter loading into synaptic vesicle
A0015844biological_processmonoamine transport
A0015872biological_processdopamine transport
A0016020cellular_componentmembrane
A0022857molecular_functiontransmembrane transporter activity
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030667cellular_componentsecretory granule membrane
A0030672cellular_componentsynaptic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0042137biological_processsequestering of neurotransmitter
A0042995cellular_componentcell projection
A0043195cellular_componentterminal bouton
A0043231cellular_componentintracellular membrane-bounded organelle
A0045202cellular_componentsynapse
A0051610biological_processserotonin uptake
A0051615biological_processhistamine uptake
A0055085biological_processtransmembrane transport
A0070083cellular_componentclathrin-sculpted monoamine transport vesicle membrane
A0098691cellular_componentdopaminergic synapse
A0098700biological_processneurotransmitter loading into synaptic vesicle
A0099123biological_processsomato-dendritic dopamine secretion
A1902600biological_processproton transmembrane transport
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues247
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU21-VAL41
AGLY390-VAL410
AVAL415-ILE435
AGLY441-LEU462
AGLN130-GLY150
AILE160-SER180
ASER190-VAL210
AVAL220-LEU242
ATHR249-GLN271
APRO292-LEU311
AGLN329-ALA352
ATRP358-ALA378

site_idSWS_FT_FI2
Number of Residues130
DetailsTOPO_DOM: Lumenal, vesicle => ECO:0000255
ChainResidueDetails
APRO42-VAL129
ASER181-ARG189
ATYR243-LYS248
AGLU312-TRP328
ALYS379-PHE389
AGLY436-GLY440

site_idSWS_FT_FI3
Number of Residues42
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
ALEU151-PRO159
ATYR211-ASN219
APRO272-ASP291
AHIS353-ARG357
AASP411-HIS414

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN84
AASN91

223166

PDB entries from 2024-07-31

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