8THR

Structure of the human vesicular monoamine transporter 2 (VMAT2) bound to tetrabenazine in an occluded conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001975	biological_process	response to amphetamine
A	0002552	biological_process	serotonin secretion by mast cell
A	0002553	biological_process	histamine secretion by mast cell
A	0005335	molecular_function	serotonin:sodium:chloride symporter activity
A	0005515	molecular_function	protein binding
A	0005813	cellular_component	centrosome
A	0005886	cellular_component	plasma membrane
A	0006091	biological_process	generation of precursor metabolites and energy
A	0006836	biological_process	neurotransmitter transport
A	0006837	biological_process	serotonin transport
A	0007268	biological_process	chemical synaptic transmission
A	0007626	biological_process	locomotory behavior
A	0008021	cellular_component	synaptic vesicle
A	0008218	biological_process	bioluminescence
A	0008504	molecular_function	monoamine transmembrane transporter activity
A	0009636	biological_process	response to toxic substance
A	0009791	biological_process	post-embryonic development
A	0015311	molecular_function	monoamine:proton antiporter activity
A	0015842	biological_process	aminergic neurotransmitter loading into synaptic vesicle
A	0015844	biological_process	monoamine transport
A	0015872	biological_process	dopamine transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0030658	cellular_component	transport vesicle membrane
A	0030667	cellular_component	secretory granule membrane
A	0030672	cellular_component	synaptic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0042995	cellular_component	cell projection
A	0043195	cellular_component	terminal bouton
A	0045202	cellular_component	synapse
A	0051610	biological_process	serotonin uptake
A	0051615	biological_process	histamine uptake
A	0051649	biological_process	establishment of localization in cell
A	0055085	biological_process	transmembrane transport
A	0070083	cellular_component	clathrin-sculpted monoamine transport vesicle membrane
A	0098691	cellular_component	dopaminergic synapse
A	0098700	biological_process	neurotransmitter loading into synaptic vesicle
A	0099123	biological_process	somato-dendritic dopamine secretion
A	1902600	biological_process	proton transmembrane transport
A	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38517752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8THR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38517752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8THR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	42
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38517752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8THR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38517752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8THR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	43
Details	Topological domain: {"description":"Lumenal, vesicle","evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38517752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8THR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38517752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8THR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38517752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8THR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38517752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8THR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38517752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8THR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38517752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8THR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38517752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8THR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38517752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8THR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38517752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8THR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38517752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8THR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37914936","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38081299","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8T6B","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---