8TE1

Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer

Summary for 8TE1

• Entry DOI: 10.2210/pdb8te1/pdb
• Descriptor: DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL, ... (5 entities in total)
• Functional Keywords: dna metyltransferase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 265202.98

Authors

Lu, J.W.,Song, J.K. (deposition date: 2023-07-05, release date: 2024-03-13, Last modification date: 2024-09-25)

• Primary citation: Lu, J.,Guo, Y.,Yin, J.,Chen, J.,Wang, Y.,Wang, G.G.,Song, J.; Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations.; Nat Commun, 15:3111-3111, 2024; PubMed: 38600075; DOI: 10.1038/s41467-024-47398-y

Experimental method

X-RAY DIFFRACTION (2.48 Å)