8TBU

Structure of human erythrocyte pyruvate kinase in complex with an allosteric activator Compound 12

Summary for 8TBU

• Entry DOI: 10.2210/pdb8tbu/pdb
• Descriptor: Pyruvate kinase PKLR, 6-[(4-hydroxyphenyl)methyl]-2,4-dimethyl-4,6-dihydro-5H-[1,3]thiazolo[5',4':4,5]pyrrolo[2,3-d]pyridazin-5-one, PYRUVIC ACID, ... (7 entities in total)
• Functional Keywords: erythrocyte pyruvate kinase, pkr, pklr, allosteric activator, glycolysis, transferase, transferase-activator complex, transferase/activator
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 474393.90

Authors

Jin, L.,Padyana, A. (deposition date: 2023-06-29, release date: 2023-12-27, Last modification date: 2024-03-20)

• Primary citation: Liu, T.,Padyana, A.K.,Judd, E.T.,Jin, L.,Hammoudeh, D.,Kung, C.,Dang, L.; Structure-Based Design of AG-946, a Pyruvate Kinase Activator.; Chemmedchem, 19:e202300559-e202300559, 2024; PubMed: 38109501; DOI: 10.1002/cmdc.202300559

Experimental method

X-RAY DIFFRACTION (2.35 Å)