8TBS

Structure of human erythrocyte pyruvate kinase in complex with an allosteric activator AG-946

Summary for 8TBS

• Entry DOI: 10.2210/pdb8tbs/pdb
• Descriptor: Pyruvate kinase PKLR, 1,6-di-O-phosphono-beta-D-fructofuranose, MANGANESE (II) ION, ... (7 entities in total)
• Functional Keywords: erythrocyte pyruvate kinase, pkr, pklr, allosteric activator, glycolysis, transferase, transferase-activator complex, transferase/activator
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 474990.68

Authors

Jin, L.,Padyana, A. (deposition date: 2023-06-29, release date: 2023-12-27, Last modification date: 2024-03-20)

• Primary citation: Liu, T.,Padyana, A.K.,Judd, E.T.,Jin, L.,Hammoudeh, D.,Kung, C.,Dang, L.; Structure-Based Design of AG-946, a Pyruvate Kinase Activator.; Chemmedchem, 19:e202300559-e202300559, 2024; PubMed: 38109501; DOI: 10.1002/cmdc.202300559

Experimental method

X-RAY DIFFRACTION (2.35 Å)