8TBS

Structure of human erythrocyte pyruvate kinase in complex with an allosteric activator AG-946

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001666	biological_process	response to hypoxia
A	0003824	molecular_function	catalytic activity
A	0004743	molecular_function	pyruvate kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006096	biological_process	glycolytic process
A	0007584	biological_process	response to nutrient
A	0009749	biological_process	response to glucose
A	0010038	biological_process	response to metal ion
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0030955	molecular_function	potassium ion binding
A	0032869	biological_process	cellular response to insulin stimulus
A	0033198	biological_process	response to ATP
A	0042866	biological_process	pyruvate biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0048029	molecular_function	monosaccharide binding
A	0051591	biological_process	response to cAMP
A	0070062	cellular_component	extracellular exosome
A	0071872	biological_process	cellular response to epinephrine stimulus
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0001666	biological_process	response to hypoxia
B	0003824	molecular_function	catalytic activity
B	0004743	molecular_function	pyruvate kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006096	biological_process	glycolytic process
B	0007584	biological_process	response to nutrient
B	0009749	biological_process	response to glucose
B	0010038	biological_process	response to metal ion
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0030955	molecular_function	potassium ion binding
B	0032869	biological_process	cellular response to insulin stimulus
B	0033198	biological_process	response to ATP
B	0042866	biological_process	pyruvate biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0048029	molecular_function	monosaccharide binding
B	0051591	biological_process	response to cAMP
B	0070062	cellular_component	extracellular exosome
B	0071872	biological_process	cellular response to epinephrine stimulus
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0001666	biological_process	response to hypoxia
C	0003824	molecular_function	catalytic activity
C	0004743	molecular_function	pyruvate kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006096	biological_process	glycolytic process
C	0007584	biological_process	response to nutrient
C	0009749	biological_process	response to glucose
C	0010038	biological_process	response to metal ion
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0030955	molecular_function	potassium ion binding
C	0032869	biological_process	cellular response to insulin stimulus
C	0033198	biological_process	response to ATP
C	0042866	biological_process	pyruvate biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0048029	molecular_function	monosaccharide binding
C	0051591	biological_process	response to cAMP
C	0070062	cellular_component	extracellular exosome
C	0071872	biological_process	cellular response to epinephrine stimulus
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0001666	biological_process	response to hypoxia
D	0003824	molecular_function	catalytic activity
D	0004743	molecular_function	pyruvate kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006096	biological_process	glycolytic process
D	0007584	biological_process	response to nutrient
D	0009749	biological_process	response to glucose
D	0010038	biological_process	response to metal ion
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0030955	molecular_function	potassium ion binding
D	0032869	biological_process	cellular response to insulin stimulus
D	0033198	biological_process	response to ATP
D	0042866	biological_process	pyruvate biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0048029	molecular_function	monosaccharide binding
D	0051591	biological_process	response to cAMP
D	0070062	cellular_component	extracellular exosome
D	0071872	biological_process	cellular response to epinephrine stimulus
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0001666	biological_process	response to hypoxia
E	0003824	molecular_function	catalytic activity
E	0004743	molecular_function	pyruvate kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006096	biological_process	glycolytic process
E	0007584	biological_process	response to nutrient
E	0009749	biological_process	response to glucose
E	0010038	biological_process	response to metal ion
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0030955	molecular_function	potassium ion binding
E	0032869	biological_process	cellular response to insulin stimulus
E	0033198	biological_process	response to ATP
E	0042866	biological_process	pyruvate biosynthetic process
E	0046872	molecular_function	metal ion binding
E	0048029	molecular_function	monosaccharide binding
E	0051591	biological_process	response to cAMP
E	0070062	cellular_component	extracellular exosome
E	0071872	biological_process	cellular response to epinephrine stimulus
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0001666	biological_process	response to hypoxia
F	0003824	molecular_function	catalytic activity
F	0004743	molecular_function	pyruvate kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006096	biological_process	glycolytic process
F	0007584	biological_process	response to nutrient
F	0009749	biological_process	response to glucose
F	0010038	biological_process	response to metal ion
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0030955	molecular_function	potassium ion binding
F	0032869	biological_process	cellular response to insulin stimulus
F	0033198	biological_process	response to ATP
F	0042866	biological_process	pyruvate biosynthetic process
F	0046872	molecular_function	metal ion binding
F	0048029	molecular_function	monosaccharide binding
F	0051591	biological_process	response to cAMP
F	0070062	cellular_component	extracellular exosome
F	0071872	biological_process	cellular response to epinephrine stimulus
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0001666	biological_process	response to hypoxia
G	0003824	molecular_function	catalytic activity
G	0004743	molecular_function	pyruvate kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006096	biological_process	glycolytic process
G	0007584	biological_process	response to nutrient
G	0009749	biological_process	response to glucose
G	0010038	biological_process	response to metal ion
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0030955	molecular_function	potassium ion binding
G	0032869	biological_process	cellular response to insulin stimulus
G	0033198	biological_process	response to ATP
G	0042866	biological_process	pyruvate biosynthetic process
G	0046872	molecular_function	metal ion binding
G	0048029	molecular_function	monosaccharide binding
G	0051591	biological_process	response to cAMP
G	0070062	cellular_component	extracellular exosome
G	0071872	biological_process	cellular response to epinephrine stimulus
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0001666	biological_process	response to hypoxia
H	0003824	molecular_function	catalytic activity
H	0004743	molecular_function	pyruvate kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006096	biological_process	glycolytic process
H	0007584	biological_process	response to nutrient
H	0009749	biological_process	response to glucose
H	0010038	biological_process	response to metal ion
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0030955	molecular_function	potassium ion binding
H	0032869	biological_process	cellular response to insulin stimulus
H	0033198	biological_process	response to ATP
H	0042866	biological_process	pyruvate biosynthetic process
H	0046872	molecular_function	metal ion binding
H	0048029	molecular_function	monosaccharide binding
H	0051591	biological_process	response to cAMP
H	0070062	cellular_component	extracellular exosome
H	0071872	biological_process	cellular response to epinephrine stimulus

Functional Information from PROSITE/UniProt

site_id	PS00110
Number of Residues	13
Details	PYRUVATE_KINASE Pyruvate kinase active site signature. IkIISKIENhEGV

Chain	Residue	Details
A	ILE308-VAL320

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11960989","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VGB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	160
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11960989","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VGF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P00549","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---