8TBQ

The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody

8TBQ の概要

• エントリーDOI: 10.2210/pdb8tbq/pdb
• 分子名称: SNS-101 Fab heavy chain, SNS-101 Fab light chain, V-type immunoglobulin domain-containing suppressor of T-cell activation, ... (6 entities in total)
• 機能のキーワード: vista, ph-selective, sns-101, pd-1, protein binding, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 132211.84

構造登録者

van der Horst, E.H.,Mukherjee, A.,Thisted, T. (登録日: 2023-06-29, 公開日: 2024-03-20)

• 主引用文献: Thisted, T.,Smith, F.D.,Zhang, G.,Feng, F.,Kleschenko, Y.,Mukherjee, A.,Jiang, Z.,Malhotra, K.,Biesova, Z.,Onumajuru, A.,Gaelle, M.,Takeuchi, Y.,Thiam, K.,Schreiber, R.D.,van der Horst, E.H.; The pH-selective anti-VISTA antibody SNS-101 displays a favorable pharmacokinetic and safety profile and promotes anti-tumoral M1 macrophage polarization in PD-1 refractory settings; To Be Published,

実験手法

X-RAY DIFFRACTION (2.593 Å)