8TBB

F9S, novel TIM-3 targeting antibody, bound to IgV domain of TIM-3

Summary for 8TBB

• Entry DOI: 10.2210/pdb8tbb/pdb
• Descriptor: T-cell immunoglobulin mucin receptor 3, F9S Fab heavy chain, F9S Fab light chain, ... (5 entities in total)
• Functional Keywords: fab, igv domain of tim-3, complex, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 60055.29

Authors

Oganesyan, V.,van Dyk, N.,Mazor, Y.,Yang, C. (deposition date: 2023-06-28, release date: 2024-08-28)

• Primary citation: Clancy-Thompson, E.,Perry, T.,Pryts, S.,Jaiswal, A.,Oganesyan, V.,van Dyk, N.,Yang, C.,Garcia, A.,Yu, W.,Moynihan, J.,Miller, C.,Mulgrew, K.,Cobbold, M.,Mazor, Y.,Hammond, S.,Pollizzi, K.; Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3; To be published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)