8T81

Influenza PAN endonuclease E23K mutant with 6-(4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid

8T81 の概要

• エントリーDOI: 10.2210/pdb8t81/pdb
• 関連するPDBエントリー: 8T5V 8T5W 8T5Z 8T67 8T6Z
• 分子名称: Polymerase acidic protein, MANGANESE (II) ION, (6M)-3-hydroxy-4-oxo-6-[(4M)-4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-2-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: influenza endonuclease, resistance, drug discovery, metal-binding pharmacophore, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Influenza A virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22901.73

構造登録者

Kohlbrand, A.J.,Cohen, S.M. (登録日: 2023-06-21, 公開日: 2024-05-08)

• 主引用文献: Kohlbrand, A.J.,Stokes, R.W.,Sankaran, B.,Cohen, S.M.; Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants.; Biochemistry, 63:264-272, 2024; PubMed: 38190441; DOI: 10.1021/acs.biochem.3c00536

実験手法

X-RAY DIFFRACTION (2.6 Å)