8T5M

SOS2 crystal structure with fragment bound (compound 14)

Summary for 8T5M

Entry DOI	10.2210/pdb8t5m/pdb
Descriptor	Son of sevenless homolog 2, 1,2-ETHANEDIOL, SULFATE ION, ... (5 entities in total)
Functional Keywords	signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	58166.42
Authors	Gunn, R.J.,Lawson, J.D.,Ivetac, A.,Ulaganathan, T.,Coulombe, R.,Fethiere, J. (deposition date: 2023-06-14, release date: 2024-01-10, Last modification date: 2024-01-24)
Primary citation	Smith, C.R.,Chen, D.,Christensen, J.G.,Coulombe, R.,Fethiere, J.,Gunn, R.J.,Hollander, J.,Jones, B.,Ketcham, J.M.,Khare, S.,Kuehler, J.,Lawson, J.D.,Marx, M.A.,Olson, P.,Pearson, K.E.,Ren, C.,Tsagris, D.,Ulaganathan, T.,Van't Veer, I.,Wang, X.,Ivetac, A. Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. J.Med.Chem., 67:774-781, 2024 Cited by PubMed: 38156904 DOI: 10.1021/acs.jmedchem.3c02140 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation