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8T5M

SOS2 crystal structure with fragment bound (compound 14)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Son of sevenless homolog 2polymer49057370.71UniProt (Q07890)
Pfam (PF00618)
Pfam (PF00617)
Homo sapiens (human)SOS-2
2B, C
(A)
1,2-ETHANEDIOLnon-polymer62.12Chemie (EDO)
3D, E, F, G
(A)
SULFATE IONnon-polymer96.14Chemie (SO4)
4H
(A)
4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenolnon-polymer287.41Chemie (YIF)
5I
(A)
waterwater18.0210Chemie (HOH)
Sequence modifications
A: 562 - 1047 (UniProt: Q07890)
PDBExternal DatabaseDetails
Gly 558-expression tag
Ala 559-expression tag
Met 560-expression tag
Ala 561-expression tag
Gln 564Pro 564conflict
Tyr 707Glu 707conflict
His 768Gln 768conflict
Ile 769Phe 769conflict
Thr 947Lys 947conflict
Arg 948Lys 948conflict
His 949Lys 949conflict
Pro 1019Cys 1019conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight57370.7
Non-Polymers*Number of molecules7
Total formula weight795.7
All*Total formula weight58166.4
*Water molecules are not included.

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PDB entries from 2024-11-20

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