8T5B
HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor EKC-110
Summary for 8T5B
Entry DOI | 10.2210/pdb8t5b/pdb |
Descriptor | Integrase, (2S)-tert-butoxy{4-(4-chlorophenyl)-2,6-dimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | integrase, viral protein |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 4 |
Total formula weight | 48182.74 |
Authors | |
Primary citation | Dinh, T.,Kvaratskhelia, M. Understanding the resistance of Y99H and A128T mutations in HIV-1 Integrase against the effective anti-HIV drugs of STP0404 and BKC11 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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