8T5B

HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor EKC-110

8T5B の概要

• エントリーDOI: 10.2210/pdb8t5b/pdb
• 分子名称: Integrase, (2S)-tert-butoxy{4-(4-chlorophenyl)-2,6-dimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: integrase, viral protein
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 48182.74

構造登録者

Dinh, T.,Kvaratskhelia, M. (登録日: 2023-06-12, 公開日: 2024-06-19)

• 主引用文献: Dinh, T.,Kvaratskhelia, M.; Understanding the resistance of Y99H and A128T mutations in HIV-1 Integrase against the effective anti-HIV drugs of STP0404 and BKC11; To Be Published,

実験手法

X-RAY DIFFRACTION (2.08 Å)