8SZM
Crystal structure of E. coli ClpP protease in complex with phosphine oxide compound ACP6-12
Summary for 8SZM
Entry DOI | 10.2210/pdb8szm/pdb |
Descriptor | ATP-dependent Clp protease proteolytic subunit, 2-{bis[5-(trifluoromethyl)pyridin-2-yl]phosphoryl}-2-methyl-N-(2-{[2-(trifluoromethyl)phenyl]sulfanyl}ethyl)propanamide (3 entities in total) |
Functional Keywords | clpp, protease, activator, antibiotic, proteostasis, hydrolase |
Biological source | Escherichia coli |
Total number of polymer chains | 28 |
Total formula weight | 651842.63 |
Authors | Mabanglo, M.F.,Houry, W.A. (deposition date: 2023-05-30, release date: 2024-09-18, Last modification date: 2024-09-25) |
Primary citation | Lin, F.,Mabanglo, M.F.,Zhou, J.L.,Binepal, G.,Barghash, M.M.,Wong, K.S.,Gray-Owen, S.D.,Batey, R.A.,Houry, W.A. Structure-Based Design and Development of Phosphine Oxides as a Novel Chemotype for Antibiotics that Dysregulate Bacterial ClpP Proteases. J.Med.Chem., 67:15131-15147, 2024 Cited by PubMed: 39221504DOI: 10.1021/acs.jmedchem.4c00773 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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