8SZI

Cryo-EM structure of PAM-free human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs

8SZI の概要

• エントリーDOI: 10.2210/pdb8szi/pdb
• EMDBエントリー: 40917
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-3, TRYPTOPHAN, PHOSPHATE ION, ... (12 entities in total)
• 機能のキーワード: family c gpcr, calcium-sensing receptor (casr), heterotrimeric g protein, cryo-em, lipid nanodiscs, positive allosteric modulator, membrane protein, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 304841.78

構造登録者

He, F.,Wu, C.,Gao, Y.,Skiniotis, G. (登録日: 2023-05-29, 公開日: 2024-02-07, 最終更新日: 2024-03-13)

• 主引用文献: He, F.,Wu, C.G.,Gao, Y.,Rahman, S.N.,Zaoralova, M.,Papasergi-Scott, M.M.,Gu, T.J.,Robertson, M.J.,Seven, A.B.,Li, L.,Mathiesen, J.M.,Skiniotis, G.; Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.; Nature, 626:1141-1148, 2024; PubMed: 38326620; DOI: 10.1038/s41586-024-07055-2

実験手法

ELECTRON MICROSCOPY (3.5 Å)