8SZF
Cryo-EM structure of cinacalcet-bound active-state human calcium-sensing receptor CaSR in lipid nanodiscs
Summary for 8SZF
Entry DOI | 10.2210/pdb8szf/pdb |
EMDB information | 40914 |
Descriptor | Extracellular calcium-sensing receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | family c gpcr, calcium-sensing receptor (casr), lipid nanodiscs, positive allosteric modulator, membrane protein, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 235899.14 |
Authors | He, F.,Wu, C.,Gao, Y.,Skiniotis, G. (deposition date: 2023-05-29, release date: 2024-02-07, Last modification date: 2024-03-13) |
Primary citation | He, F.,Wu, C.G.,Gao, Y.,Rahman, S.N.,Zaoralova, M.,Papasergi-Scott, M.M.,Gu, T.J.,Robertson, M.J.,Seven, A.B.,Li, L.,Mathiesen, J.M.,Skiniotis, G. Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor. Nature, 626:1141-1148, 2024 Cited by PubMed: 38326620DOI: 10.1038/s41586-024-07055-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.8 Å) |
Structure validation
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