8SPN

Crystal structure of macrophage migration inhibitory factor in complex with T614

Summary for 8SPN

• Entry DOI: 10.2210/pdb8spn/pdb
• Descriptor: Macrophage migration inhibitory factor, SULFATE ION, ISOPROPYL ALCOHOL, ... (6 entities in total)
• Functional Keywords: inhibitor, enzyme, complex, isomerase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 37783.85

Authors

Pantouris, G.,Lolis, E. (deposition date: 2023-05-03, release date: 2024-05-01)

Primary citation

Bloom, J.,Pantouris, G.,He, M.,Aljabari, B.,Mishra, L.,Manjula, R.,Parkins, A.,Lolis, E.J.,Al-Abed, Y.
Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose.
Mol Med, 30:43-43, 2024

PubMed Abstract: Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in multiple inflammatory and non-inflammatory diseases, including liver injury induced by acetaminophen (APAP) overdose. Multiple small molecule inhibitors of MIF have been described, including the clinically available anti-rheumatic drug T-614 (iguratimod); however, this drug's mode of inhibition has not been fully investigated.

PubMed: 38539088
DOI: 10.1186/s10020-024-00803-0

Experimental method

X-RAY DIFFRACTION (1.73 Å)