8SML

hPAD4 bound to inhibitory Fab hI365

Summary for 8SML

• Entry DOI: 10.2210/pdb8sml/pdb
• EMDB information: 40590
• Descriptor: Protein-arginine deiminase type-4, Fab hI365 light chain, Fab hI365 heavy chain, ... (4 entities in total)
• Functional Keywords: complex, deiminase, enzyme, arginine, inflammation, calcium binding, fab, immune system, hydrolase-immune system complex, hydrolase/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 251592.69

Authors

Maker, A.,Verba, K.A. (deposition date: 2023-04-26, release date: 2024-03-06, Last modification date: 2024-03-13)

• Primary citation: Zhou, X.,Kong, S.,Maker, A.,Remesh, S.G.,Leung, K.K.,Verba, K.A.,Wells, J.A.; Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4.; Nat.Chem.Biol., 2024; PubMed: 38308046; DOI: 10.1038/s41589-023-01535-8

Experimental method

ELECTRON MICROSCOPY (3.3 Å)