8SML

hPAD4 bound to inhibitory Fab hI365

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0004668	molecular_function	protein-arginine deiminase activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0006338	biological_process	chromatin remodeling
A	0016787	molecular_function	hydrolase activity
A	0019827	biological_process	stem cell population maintenance
A	0032991	cellular_component	protein-containing complex
A	0036211	biological_process	protein modification process
A	0042802	molecular_function	identical protein binding
A	0043687	biological_process	post-translational protein modification
A	0045087	biological_process	innate immune response
A	0046872	molecular_function	metal ion binding
A	0140794	molecular_function	histone arginine deiminase activity
A	0140795	molecular_function	histone H3R2 arginine deiminase activity
A	0140796	molecular_function	histone H3R8 arginine deiminase activity
A	0140797	molecular_function	histone H3R17 arginine deiminase activity
A	0140798	molecular_function	histone H3R26 arginine deiminase activity
D	0002376	biological_process	immune system process
D	0004668	molecular_function	protein-arginine deiminase activity
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006325	biological_process	chromatin organization
D	0006334	biological_process	nucleosome assembly
D	0006338	biological_process	chromatin remodeling
D	0016787	molecular_function	hydrolase activity
D	0019827	biological_process	stem cell population maintenance
D	0032991	cellular_component	protein-containing complex
D	0036211	biological_process	protein modification process
D	0042802	molecular_function	identical protein binding
D	0043687	biological_process	post-translational protein modification
D	0045087	biological_process	innate immune response
D	0046872	molecular_function	metal ion binding
D	0140794	molecular_function	histone arginine deiminase activity
D	0140795	molecular_function	histone H3R2 arginine deiminase activity
D	0140796	molecular_function	histone H3R8 arginine deiminase activity
D	0140797	molecular_function	histone H3R17 arginine deiminase activity
D	0140798	molecular_function	histone H3R26 arginine deiminase activity

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
C	TYR207-HIS213
B	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"evidences":[{"source":"PubMed","id":"15247907","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	34
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15247907","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17002273","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Modified residue: {"description":"Citrulline","evidences":[{"source":"PubMed","id":"20201080","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 594

Chain	Residue	Details
A	ASP350	electrostatic stabiliser
A	HIS471	proton acceptor, proton donor
A	ASP473	electrostatic stabiliser

---

site_id	MCSA2
Number of Residues	3
Details	M-CSA 594

Chain	Residue	Details
D	ASP350	electrostatic stabiliser
D	HIS471	proton acceptor, proton donor
D	ASP473	electrostatic stabiliser

---