8SMC

Cryo-EM structure of LRRK2 bound with type-I inhibitor DNL201

Summary for 8SMC

Entry DOI	10.2210/pdb8smc/pdb
EMDB information	40588
Descriptor	non-specific serine/threonine protein kinase, GUANOSINE-5'-DIPHOSPHATE, 2-methyl-2-(3-methyl-4-{[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1H-pyrazol-1-yl)propanenitrile (3 entities in total)
Functional Keywords	parkinson's disease, kinase, activation, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	137625.99
Authors	Sun, J.,Zhu, H. (deposition date: 2023-04-26, release date: 2024-01-03)
Primary citation	Zhu, H.,Tonelli, F.,Turk, M.,Prescott, A.,Alessi, D.R.,Sun, J. Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Science, 382:1404-1411, 2023 Cited by PubMed: 38127736 DOI: 10.1126/science.adi9926 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.02 Å)

Structure validation