8SMC
Cryo-EM structure of LRRK2 bound with type-I inhibitor DNL201
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | non-specific serine/threonine protein kinase | polymer | 1201 | 136843.5 | 1 | UniProt (Q17RV3) Pfam (PF08477) Pfam (PF16095) Pfam (PF25497) Pfam (PF00069) Pfam (PF23748) UniProt (by SIFTS) (Q5S007) | Homo sapiens (human) | |
| 2 | B (C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 3 | C (C) | 2-methyl-2-(3-methyl-4-{[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1H-pyrazol-1-yl)propanenitrile | non-polymer | 339.3 | 1 | Chemie (TVT) PubChem (69093374) |
Sequence modifications
C: 1327 - 2527 (UniProt: Q17RV3)
| PDB | External Database | Details |
|---|---|---|
| Arg 1732 | Met 1732 | conflict |
| Thr 2408 | Met 2408 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 136843.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 782.5 | |
| All* | Total formula weight | 137626.0 |
