8SKP

X-ray structure of the NDM-4 beta-lactamase from Klebsiella pneumonia in complex with 1-hydroxypyridine-2(1H)-thione-6-carboxylic acid

Summary for 8SKP

Entry DOI	10.2210/pdb8skp/pdb
Related	8sk2 8sko
Descriptor	Metallo-beta-lactamase type 2, ZINC ION, 1-hydroxy-6-sulfanylidene-1,6-dihydropyridine-2-carboxylic acid, ... (5 entities in total)
Functional Keywords	beta-lactamase, hydrolase, metallo-enzyme, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	24592.28
Authors	Thoden, J.B.,Holden, H.M. (deposition date: 2023-04-20, release date: 2023-08-23, Last modification date: 2023-10-04)
Primary citation	Thoden, J.B.,Benin, B.M.,Priebe, A.,Shin, W.S.,Muthyala, R.,Sham, Y.Y.,Holden, H.M. Characterization of a novel inhibitor for the New Delhi metallo-beta-lactamase-4: Implications for drug design and combating bacterial drug resistance. J.Biol.Chem., 299:105135-105135, 2023 Cited by PubMed: 37549809 DOI: 10.1016/j.jbc.2023.105135 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation