8SKP
X-ray structure of the NDM-4 beta-lactamase from Klebsiella pneumonia in complex with 1-hydroxypyridine-2(1H)-thione-6-carboxylic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Metallo-beta-lactamase type 2 | polymer | 230 | 24228.2 | 1 | UniProt (C7C422) Pfam (PF00753) | Klebsiella pneumoniae | B2 metallo-beta-lactamase,Beta-lactamase type II,Metallo-beta-lactamase NDM-1,Metallo-beta-lactamase type II,New Delhi metallo-beta-lactamase-1,NDM-1 |
| 2 | B, C (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D (A) | 1-hydroxy-6-sulfanylidene-1,6-dihydropyridine-2-carboxylic acid | non-polymer | 171.2 | 1 | Chemie (WAF) | |||
| 4 | E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | F (A) | water | water | 18.0 | 232 | Chemie (HOH) |
Sequence modifications
A: 42 - 270 (UniProt: C7C422)
| PDB | External Database | Details |
|---|---|---|
| Gly 41 | - | expression tag |
| Leu 154 | Met 154 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24228.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 364.1 | |
| All* | Total formula weight | 24592.3 |
