8SKP

X-ray structure of the NDM-4 beta-lactamase from Klebsiella pneumonia in complex with 1-hydroxypyridine-2(1H)-thione-6-carboxylic acid

8SKP の概要

• エントリーDOI: 10.2210/pdb8skp/pdb
• 関連するPDBエントリー: 8sk2 8sko
• 分子名称: Metallo-beta-lactamase type 2, ZINC ION, 1-hydroxy-6-sulfanylidene-1,6-dihydropyridine-2-carboxylic acid, ... (5 entities in total)
• 機能のキーワード: beta-lactamase, hydrolase, metallo-enzyme, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24592.28

構造登録者

Thoden, J.B.,Holden, H.M. (登録日: 2023-04-20, 公開日: 2023-08-23, 最終更新日: 2023-10-04)

• 主引用文献: Thoden, J.B.,Benin, B.M.,Priebe, A.,Shin, W.S.,Muthyala, R.,Sham, Y.Y.,Holden, H.M.; Characterization of a novel inhibitor for the New Delhi metallo-beta-lactamase-4: Implications for drug design and combating bacterial drug resistance.; J.Biol.Chem., 299:105135-105135, 2023; PubMed: 37549809; DOI: 10.1016/j.jbc.2023.105135

実験手法

X-RAY DIFFRACTION (1.3 Å)