8SIF

Crystal structure of Escherichia coli HPPK in complex with bisubstrate inhibitor HP-101

Summary for 8SIF

• Entry DOI: 10.2210/pdb8sif/pdb
• Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-{(2R,4R)-1-[3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]-2-carboxypiperidin-4-yl}-5'-thioadenosine (3 entities in total)
• Functional Keywords: hppk, bisubstrate inhibitor, hp-101, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 18698.38

Authors

Shaw, G.X.,Shi, G.,Ji, X. (deposition date: 2023-04-16, release date: 2024-07-03)

• Primary citation: Shi, G.,Shaw, G.X.,Ji, X.; The first bisubstrate inhibitor of HPPK exhibiting cell permeability; To be published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)