8SI8
Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in complex with inhibitor VER155008 in closed state
Summary for 8SI8
Entry DOI | 10.2210/pdb8si8/pdb |
Related | 8SI2 8SI3 8SI4 8SI5 8SI6 8SI7 |
EMDB information | 40496 40497 40498 40499 40500 40501 40502 |
Descriptor | Transient receptor potential cation channel subfamily M member 7, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, ... (6 entities in total) |
Functional Keywords | transient receptor potential m family member 7, trp, channel, trpm7, trp channels, membrane protein, magnesium channel, n1098q, inhibitor, ligand, ver155008 |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 4 |
Total formula weight | 633014.82 |
Authors | Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2023-04-14, release date: 2023-05-17, Last modification date: 2023-05-24) |
Primary citation | Nadezhdin, K.D.,Correia, L.,Narangoda, C.,Patel, D.S.,Neuberger, A.,Gudermann, T.,Kurnikova, M.G.,Chubanov, V.,Sobolevsky, A.I. Structural mechanisms of TRPM7 activation and inhibition. Nat Commun, 14:2639-2639, 2023 Cited by PubMed: 37156763DOI: 10.1038/s41467-023-38362-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.99 Å) |
Structure validation
Download full validation report