8SDO

ATAD2 bromodomain in complex with "oncohistone" mutation H4S1CK5ac (res 1-15) ligand

Summary for 8SDO

• Entry DOI: 10.2210/pdb8sdo/pdb
• Descriptor: ATPase family AAA domain-containing protein 2, Histone H4 (3 entities in total)
• Functional Keywords: bromodomain, epigenetics, nuclear protein, cancer, histone mutations, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 19205.77

Authors

Malone, K.L.,Nix, J.C.,Glass, K.C. (deposition date: 2023-04-07, release date: 2024-06-05)

• Primary citation: Phillips, M.,Malone, K.L.,Boyle, B.W.,Montgomery, C.,Kressy, I.A.,Joseph, F.M.,Bright, K.M.,Boyson, S.P.,Chang, S.,Nix, J.C.,Young, N.L.,Jeffers, V.,Frietze, S.,Glass, K.C.; Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains.; J.Med.Chem., 67:8186-8200, 2024; PubMed: 38733345; DOI: 10.1021/acs.jmedchem.4c00210

Experimental method

X-RAY DIFFRACTION (2.01 Å)