8SDG

Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC25.43

Summary for 8SDG

Entry DOI	10.2210/pdb8sdg/pdb
Descriptor	Neutralizing antibody CC25.43 heavy chain, Neutralizing antibody CC25.43 light chain, Spike protein S1, ... (4 entities in total)
Functional Keywords	sars-cov-2, coronavirus, antibody, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	141625.26
Authors	Yuan, M.,Wilson, I.A. (deposition date: 2023-04-06, release date: 2024-03-13, Last modification date: 2024-03-20)
Primary citation	Song, G.,Yuan, M.,Liu, H.,Capozzola, T.,Lin, R.N.,Torres, J.L.,He, W.T.,Musharrafieh, R.,Dueker, K.,Zhou, P.,Callaghan, S.,Mishra, N.,Yong, P.,Anzanello, F.,Avillion, G.,Vo, A.L.,Li, X.,Makhdoomi, M.,Feng, Z.,Zhu, X.,Peng, L.,Nemazee, D.,Safonova, Y.,Briney, B.,Ward, A.B.,Burton, D.R.,Wilson, I.A.,Andrabi, R. Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift. Biorxiv, 2023 Cited by PubMed: 37162858 DOI: 10.1101/2023.04.26.538488 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.71 Å)

Structure validation